3M™ Polisher ST
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Details
Highlights
- Unaffected by process fluid turbidity up to 40 NTU
- The 3M™ Polisher ST is single use multi-mechanism membrane adsorber which contains a Q-functional anion exchange non woven media and guanidinium functionalized membrane. This product removes residual turbidity, DNA and HCP and provides robust virus clearance for improved downstream/polishing purification
- Single-use technology as a cost-efficient option to increase biomass production by delivering high purity and yield in the downstream polishing unit operation in therapeutic recombinant protein process in biologically relevant operating conditions
- Replaces downstream AEX polishing column for reduction of HCP and virus in a salt tolerant (ST) manner as a single-use solution
The 3M™ Polisher ST is a fully encapsulated single-use anion exchange (AEX) product. It is intended to reduce host cell protein, viruses, and other negatively charged contaminants in a flow-through polishing chromatography mode in biopharmaceutical process streams. The 3M™ Polisher ST is a synthetic, hybrid purifier containing two complementary AEX-functional media: a quaternary ammonium (“Q”) functional nonwoven and a guanidinium-functional membrane. The Q-functional nonwoven provides reduction of turbidity (when present) and DNA. It also provides a portion of the product’s AEX capacity for HCP and virus reduction. Guanidinium functionalized membrane downstream of the functionalized nonwoven provides additional AEX polishing capacity. The novel guanidinium functionality of the downstream AEX polishing membrane mimics the amino acid, arginine, one of the three positively charged naturally occurring standard amino acids that make up proteins and is responsible for viral clearance and high salt tolerance.
Specifications
| Autoclavable | Yes |
| Brands | 3M™ |
| Capsule Material | Polysulfone, Polypropylene, Polystyrene, Glass Filled Polyphenylene Ether |
| Effective Filtration Area (metric) | 0.23 cm², 1 cm², 1.6 cm², 4 m², 25 cm², 170 m², 340 cm², 1020 cm² |
| End Modification | 3/4 in Sanitary Connectors, 1 1/2 in Sanitary Connectors, Luer Loc |
| Factory Integrity Tested | Capsule Leak Test |
| Fill Volume | 1.7 mL, 1.8 mL, 4.4 L, 5.6 mL, 19.8 mL, 40 L, 45 mL, 730 L |
| Filter Material | Quaternary Ammonium Functional Polymer Grafted to a Polypropylene Nonwoven Guanidinium Functional Polyamide Membrane |
| Filter Technology | Anion exchange chromatography |
| Filter Type | Single Use |
| Flow Rate (metric) | 1 Millilitre per Minute, 2.3 Millilitre per Minute, 4 Millilitre per Minute, 25 Litre per minute, 170 Millilitre per Minute, 340 Millilitre per Minute, 1020 Millilitre per Minute |
| Gamma Compatible | No |
| Gamma Sterilized | No |
| Gasket/O-ring Material | Fluorocarbon, Silicone |
| Industries | Life Sciences |
| Inlet Outlet Size | 1.5", 3/4" |
| Inlet/Outlet Connections | 3/4 in Sanitary Connectors, 1 1/2 in Sanitary Connectors, Luer Loc |
| Maximum Operating Pressure (Metric) | 2.8 bar, 3.1 bar, 3.4 bar |
| Maximum Operating Temperature (Celsius) | 40 ℃ |
| Membrane Type | Polyamide |
| Micron Rating | 0.8 μm |
| Net Weight (Metric) | 1.1 kg, 1.2 kg, 1.8 g, 3.8 kg, 10 g, 12.7 g, 15.5 kg, 72 g, 78 kg |
| Product Series | Polisher ST |
| Shelf Life | 2 Year |
| Storage Temperature (Celsius) | 0 °C - 30 °C |
| Temperature Range (Celsius) | 0 °C - 40 °C |
| Units per Case | 1.0, 2.0, 4.0 |
| Overall Diameter (Metric) | 4.3 cm, 7.7 cm, 24.1 cm, 45 cm, 45.2 cm |
| Overall Height (Metric) | 4.8 cm, 4.9 cm, 5.9 cm, 7.7 cm, 8.6 cm, 10.1 cm, 15.2 cm, 22.2 cm |
Resources
3M™ Polisher ST Technical Datasheet (English)Data Sheets
(PDF, 2MB)
